The answer to the question is "No," it's not dramatically meaningful. The play was designed so the audience would have trouble hearing many of the lines. Surely someone as skilled as Joanna Gleason knows how to project when there aren't mikes throwing her voice into the audience. Yet, sitting in the middle of the audience I found myself craning to hear what was being said on stage. Obviously, this is the director's choice, or maybe the writer's.
After listening intently to the sitcom dialogues, I found myself not trying quite so hard to hear. I didn't think it was worth the trouble despite the cost of the ticket.