Like Haddon's splendid debut novel, The Curious Incident of the Dog in the Night-Time, narrated by autistic teenager Christopher, A Spot of Bother also encumbers its main character with a psychological disorder. Hypochondria, however, isn't nearly so singular a syndrome as Asperger's and the meticulous charting of George's emotional weather sometimes wears. Christopher's obsessive reflections didn't appear indulgent, but George's meticulous mental and physical inventories (rendered in a third-person narration) often do.

Haddon catalogs in squirm-inducing detail. George, examining himself in the bathroom mirror, finds that "every square inch held some new terror. Dark brown moles, wrinkled like sultanas; freckles clumped into archipelagoes of chocolate-colored islands. . . . His skin had become a zoo of alien life forms." Though he mercifully interrupts George's torments with chapters devoted to other members of the family, these sections function mostly as reprieve, never inducing the same stomach-churning immediacy or interest. Haddon reserves all the best comic and dramatic set pieces for George—the toast he offers his daughter on the occasion of her second marriage is the icing on the wedding cake of George's lapses. His champagne-raised address to the happy couple: "We're all going to die."