“That’s four years’ worth of poop,” a doctor remarks when Eugene (Zach Cregger)—who wakes up from a coma after his best friend, Tucker (Trevor Moore), wallops him with a baseball bat, only to discover that his virginal high-school sweetheart is now a Playboy centerfold—voids his bowels. Miss March, which Whitest Kids U’ Know Cregger and Moore also co-wrote and co-directed, sprays like an exploding colostomy bag for 89 minutes. Only a moron would expect a dude road-trip-sex comedy to be more than an aggressive expression of male sexual anxiety, but really. When did women become such vile creatures that they must be stabbed in the face with a fork after a botched blowjob, become near roadkill, and drink dog pee (and love it!)? To make assholes respect you, ladies, try this: Become a Bunny to pay your vegetable boyfriend’s medical bills while saving yourself to have sex with him, or a Slavic lesbian who ingeniously transforms a Perrier bottle into a dildo. Hugh Hefner shows up to give an addled lecture after Eugene and Tucker make it to the Playboy Mansion, and you think: Wasn’t it just last summer that he so sweetly played himself in The House Bunny?